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SCFAs subsequently attenuate inflammation and oxidative stress through G protein-coupled receptor (GPR43) activation in renal tubular cells and podocytes, enhance mitochondrial functionality, and ameliorate renal complications including glomerular hyperfiltration and renal fibrogenesis (Zhong Z

[DOI] [PubMed] [Google Scholar] 34.Godwin AK, Meister A, ODwyer PJ, Huang CS, Hamilton TC, Anderson ME

Fatal neurodegenerative conditions may result from the accumulation of abnormally folded protease-resistant isoforms of host cellular sialo-glycoproteins (i.e., prion proteins) [74]

Tumors may employ targeted oxPTMs to both sustain cancer pro-oncogenic signaling and metastasis 20,22 , but also to directly influence metabolic pathways