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In both in vitro and in vivo models, the molecular mechanism of inhibition by V-9302 is linked to decreased mTOR activity, which is consistent with lowered glutamine transport and metabolism

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Three-dimensional structures of TRPM2 and TRPM7 In the last several years, the three-dimensional structures of TRP channels have become well elucidated owing to the studies with applying cryo-electron microscopy (cryo-EM), as recently reviewed (Huffer et al., 2020

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