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Scriver CR, Beaudet AL, Sly WS, Valle D (eds) (New York, NY: McGraw-Hill) Franken DG, Boers GHJ, Blom HJ, Trijibels FJM and Kloppenborg PW (1994) Treatment of mild hyperhomocysteinemia in vascular disease patients

Low-grade systemic inflammation driven by several mediators previously debated, such as LPS, bacterial translocation and the increased proinflammatory cytokines and Th1 response, are all contributing to an immunological response in the brain [139]