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Globally available over-the-counter 9 Included in: WHO policy recommendation and Model List of Essential Medicine since 2009 30-32 European Network for Smoking and Tobacco Prevention (ENSP) Tobacco Dependence Treatment Guidelines 33 NRT Combination Therapy is recommended by NICE as a first-line treatment option8 NRT single therapy is recommended by NICE as a second-line treatment option 8 Cytisine: Suitable for 18+18 Included in: World Health Organizations Policy Recommendation and Model List of Essential Medicines 2024 30.31 ENSP Tobacco Dependence Treatment Guidelines 33 Under consultation to add as first line treatment option 8 Varenicline: Suitable for 18+ 19 Included in: World Health Organizations Policy Recommendation and Model List of Essential Medicines 2021 30.31 ENSP Tobacco Dependence Treatment Guidelines 33 Varenicline is recommended by NICE as a first-line treatment option 8 Bupropion: Suitable for 18+20 Included in: World Health Organizations Policy Recommendation and Model List of Essential Medicines 2021 30.31 ENSP Tobacco Dependence Treatment Guidelines 33 Bupropion is recommended by NICE as a second-line treatment option 8 To keep in mind: NRT Combination Therapy is one of the most effective ways to help your patient quit for good 8 Speed of action and cravings relief Observational field studies indicate that cue-induced cravings are substantially responsible for relapse to smoking 35

[25] The Toll of Tobacco in Georgia. Campaign for Tobacco-Free Kids

Researchers attribute these declines in consumption to increased cigarette prices (via taxation) and other factors, such as enactment of smokefree air laws and increased public awareness of the health risks associated with smoking (CDC, 2014a