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It is related to the extensive constriction of the bronchial tree in response to inhaled stimuli, leading to the narrowing of the airways, an increase in air flow resistance, and a reduced air flow, described often as decline in FEV1, thus leading to impaired lung function [185,186]

Oxidative stress is the disturbance in the balance between the generation of free radicals, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), and antioxidant defenses, and can cause oxidative damage to diverse cellular components, such as membranes, proteins, and DNA

Liu, M., Yuan, B., Jin, X., Zhu, M., Xu, H., Xie, G., et al., Front

Macnee, W