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Thus, some diseases, including diabetes, can also play the role of disruptors of the intestinal barrier

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Activation of TIGIT signaling through agonists has been shown to suppress Th17 cell infiltration and attenuate inflammation, suggesting that TIGIT+ Tregs contribute to the resolution of immune-mediated tissue damage ( PD-1+ and TIGIT+ Tregs migrate to sites of inflammation in a chemokine receptor-dependent manner, with CCR6 and CCR7 playing pivotal roles in their tissue homing

10.1007/s12274-021-3432-x [DOI] [Google Scholar] Zhao Z., Song X., Zhang Y., Zeng B., Wu H., Guo S