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In addition, oxidative stress involved several covalent modifications in tau such as disulphide bridge formation, which resulted in tau misfolding, aggregation, hyperphosphorylation and subsequent removal of tau from MT [188-190]

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For example, another study demonstrated that supplementing with CoQ10 could restore the decreased antioxidant capacity caused by DHODH inhibition and reduce ferroptosis (Lyu et al., 2022)