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Genome-wide association studies (GWAS) identify PICALM as a major AD risk factor, second only to APOE and BIN1 (Van Acker et al., 2019)

Furthermore, while preserving colonic tight junction protein expression, it inhibits NLRP3-ASC-caspase-1 inflammasome pathway activation in intestinal epithelial cells, thereby diminishing epithelial barrier compromise and uremic toxin translocation (Long et al., 2024)

& Bickle, Q

Given these results, we measured the ability of a larger set of Aur R lines to compete with wild-type YFP-expressing RH strain parasites in the absence or presence of auranofin by quantifying their contribution to the culture at 6 days (Figure 2)