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Here, FA mediates active targeting of the NPs to oral cancer tumors, and the disulfide bond is cleaved under high concentrations of GSH, enabling the precise release of paclitaxel at the tumor site through redox reactions, thus achieving an anti-tumor effect

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Stem Cells 34 (3), 653667

However, the molecular structure of glutathione contains active sulfhydryl group (-SH), which is susceptible to oxidation reaction by external environmental factors, such as light, humidity, high temperature environment