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- GRAS Approved: Recognized by the US FDA as Generally Recognized as Safe. - Significant Benefits over NSAIDs: In animal studies, CelaCor was as effective as repeated doses of naproxen or ibuprofen in suppressing polyarthritis and three times more efficacious than aspirin

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N Engl J Med 254(19):877885 Mignat C, Wille U, Ziegler A (1995) Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes