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There is a strong evidence that the GSTM1 null genotype increases the risk of adverse effects from cyclophosphamide, regardless of other patient characteristics (age, gender, kidney function, and total CYC dose), with the odds ratio was 3.345, compared to those with functioning GSTM1 gene ( GSTM1 null genotype and increased CYC-related adverse effects, particularly when adjusted for clinical variables, others have found no relationship in the context of short-term high-dose regimens ( GSTP1 gene encodes glutathione S-transferase Pi 1, an enzyme involved in the phase II detoxification of reactive drug metabolites, including those generated during cyclophosphamide (CYC) metabolism

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Future Prospects in Stem Cell Research for Autism The future of stem cell research for autism holds significant promise, with various approaches being explored to treat autism spectrum disorder