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Metformin treatment in heart failure with preserved ejection fraction: a systematic review and meta-regression analysis

Secondary outcomes Any adverse event during the course of the study was monitored and reported to the study staff at week 6 (visit 5) or week 12 (visit 8) in the clinic or directly to principle investigator throughout the study

42 Evidence shows that early inflammation causes brain injury and results in neuronal lesions, 43 suggesting that inflammation is a vital mediator of secondary brain injury