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A study on use of bacoside A and B isolated from Bacopa monnieri has shown an improvement in cognitive defects in schizophrenic model by increasing vesicular glutamate transporter 2 in cingulate gyrus region (Wetchateng and Piyabhan, 2014)

Glu and GABA, the primary excitatory and inhibitory neurotransmitters in the human brain, were included because animal and post-mortem studies have implicated them in the pathophysiology of SZ ( Methods This study was approved by the University of Maryland Baltimore and the Johns Hopkins University School of Medicine Institutional Review Boards, and all participants provided written informed consent prior to study enrollment

We hypothesize that targeting the regulatory mechanisms of trained immunity may lead to novel therapeutic strategies that more effectively control inflammation and improve disease outcomes