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Although glutamine is required as an alternative fuel for the tricarboxylic acid cycle (TCA) to produce ATP, it also contributes to a wide range of pathways in cells, producing amino acids, nucleotides and fatty acids as well as playing an important role in reactive oxygen species (ROS) homeostasis, mTOR activation and the hexosamine biosynthesis pathway (Figure 1)

The degree of symmetry and clustering in the funnel plot was used to assess the likelihood of publication bias

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