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Ciriolo et al., 1997)

[DOI] [PMC free article] [PubMed] [Google Scholar] 372.Anzai H., Yoshimoto S., Okamura K., Hiraki A., Hashimoto S

In addition, the increasing of oxidative and nitrosative stress in the heart during aging and the decreasing of hydrogen sulfide (H 2 S) concentration along with a decline of a constitutive synthesis of nitric oxide (NO) collectively lead to the dysfunction of mitochondrial mechanisms, in particular to the formation of a non-selective channelsthe mitochondrial permeability transition pores (mPTP) in the high-conductance mode, which is the cause of many pathological conditions (Strutynska et al., 2016