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The biphasic response suggests possible mechanisms: lower doses (nanogram range) might work through growth factor upregulation and signaling cascade amplification, while higher doses (microgram range) might involve direct receptor activation or substrate provision for cellular repair

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Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimers disease

Several studies with higher doses of sulforaphane in mice describe toxicities that require careful attention to risk-benefit analyses and determination of therapeutic or prophylactic indices