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La sntesis artificial total de la B 12 fue reportada por Robert Burns Woodward [12] y Albert Eschenmoser en 1972, [13] y sigue siendo una de las hazaas clsicas de la sntesis orgnica

Additionally, we estimated an ongoing annual burden of 46 hours per hospital with a cost of $3,610.88 per hospital, resulting in a total national burden of 276,092 hours (46 hours 6,002 hospitals) and total cost of $21,672,502 ($3,610.88 6,002 hospitals), to make required annual updates to the hospitals' standard charge information

With payers tightening requirements and documentation standards becoming more detailed, the clinics that thrive will be the ones that stay proactive and adapt quickly