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doi: 10.3389/fendo.2022.1092837 Received 08 November 2022 Accepted 12 December 2022 Published 04 January 2023 Volume 13 - 2022 Edited by Luna Samanta, Ravenshaw University, India Reviewed by Jelena Djordjevic, Faculty of Biology, University of Belgrade, Serbia

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Treatment with AR antagonist flutamide increased H 2 O 2 levels by approximately 2.4-fold and decreased MMP and ATP production in hepatocytes (120), which further demonstrates the important role of androgens/AR in regulating cellular oxidative stress levels