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Vitamin B12 and Neurotransmitters Vitamin B12 contributes in two ways to the synthesis and function of what are known as the monoamine neurotransmitters, which operate both as hormones and neurotransmitters (messengers in the nervous system): B12 stimulates the creation of tetrahydrobiopterin (BH4), an important coenzyme of neurotransmitter synthesis (46, 47) B12 is needed for the synthesis of methionine, which is further converted into S-adenosylmethionine (SAM) and also plays a role in the synthesis of some neurotransmitters (48 50) Some of the neurotransmitters influenced by the vitamin are: Dopamine Adrenaline Noradrenaline Melatonin Serotonin In addition, vitamin B12 influences Acetylcholine All of these neurotransmitters and hormones perform important functions in the central nervous system and have a major impact on perception, mood and cognitive processing