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[DOI] [PubMed] [Google Scholar] 52.Veronesi B, Oortgiesen M

Conversely, LCN2 knockdown in the context of SPI1 overexpression led to a 15.5% decrease in Saos-2 cells (131.01 0.22 to 110.77 0.06) and an 18.9% decrease in MG-63 cells (133.69 0.19 to 108.28 0.38) ( Figure 5C )

This linker makes the conjugate more stable in the blood and releases the active metabolite of DM1, lysine-MCC-DM1, after the antibody molecule is digested by proteases inside the cancer cells