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Gene-editing therapies aim to correct the genetic defects or pathological processes underlying PD at their source, with the goal of directly intervening in the disease's genetic or molecular etiology, protecting neurons, and halting or delaying disease progression [214]

Mean visual analog scale scores were 21.0 (standard deviation 18.2, range 0-65) for buffered injections and 27.9 (standard deviation 21.6, range 0-90) for non-buffered injections

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More recently, to target the vasculogenic mimicry (induced by hypoxia and rapidly invading tumor cells) by platelet mimetic pH/redox sensitive nanogels co-loaded with doxorubicin (120 nm size, 16 mV zeta potential) were developed by Li and co-workers