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Several technical reasons may explain our distinctive findings, including differences in the microbiome sampling site, the limited n per group, singly housing mice, or the use of highly similar lean, Western, and high-fat diets which systematically exchanged fat content with carbohydrate content

57 In the skin, muscle, and connective tissues, reduced ATP7A function results in decreased activity of lipoxygenase (LOX), which oxidizes the lysine and hydroxylysine in elastin and collagen

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