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For neuroinflammation, others have demonstrated elevated levels in PLWH compared to HIV- controls [19,20,21], while we demonstrated that HIV- cigarette smokers who smoked to satiety [37] or underwent overnight abstinence [38] had lower whole brain (WB) standardized uptake values (SUVs) on PET scanning than HIV- non-smokers (15.517.0% across studies), indicating reduced neuroinflammatory function from smoking