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Orphan G-protein-coupled receptor 124 (Gpr124), a coactivator of the Wnt/-catenin pathway, also impacts angiogenesis (Zhao et al., 2015a)

This point is relevant as it is well-known that the immune response needs both the help mediated by the recognition of CD4+ T cells of MHC-II-restricted peptides and the lytic activity of CD8+ T cells restricted to MHC-I antigens to eliminate tumor cells (185) ( Figure 4 )

Second, extracellular iron (Fe 3+ ) binds to TF and can enter macrophages via TFR1

Hepatology 64:311312 Yu J, Wang JQ (2021) Research mechanisms of and pharmaceutical treatments for ferroptosis in liver diseases