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Its ability to penetrate the BBB, its metabolic stability, and its significant efficacy in restoring cognitive and motor functions in animal models of AD and PD, likely through modulating the HGF/c-Met system, position it as a highly promising therapeutic candidate for these debilitating neurodegenerative diseases [2]

Mol Cell Biochem 476, 24212427 (2021)

VDAC was demonstrated to be able to dictate cell death and survival, that is, a decrease in VDAC reduces cell viability

Methadone , a full opioid agonist, has decades of evidence supporting its effectiveness, particularly in cases of high-severity opioid dependence