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This "paradoxical response" (where treatment temporarily makes symptoms worse) includes: Numbness and tingling Shooting pains Joint pain Increased sensitivity Temporary inflammation (swelling and irritation) While these symptoms generally indicate that treatment is working (as nerves begin to repair themselves), they can be distressing for patients and may require additional treatment for comfort

J Neurol Neurosurg Psychiatry 75:17371741 Yu RL, Tan CH, Wu RM (2015) The impact of nocturnal disturbances on daily quality of life in patients with Parkinsons disease

In other embodiments, the invention encompasses use of NNMT inhibitors for treating a muscular dystrophy disease comprising contacting one or more cells with one or more NNMT inhibitors

The variable region may reflect the adaptive changes of different species during the evolutionary process