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Cell 144 , 646674 (2011) M.F

10.3390/ijms241914576 142 SunH.SaeediP.KarurangaS.PinkepankM.OgurtsovaK.DuncanB

Glutathione supports liver function by acting as a key substrate of the hepatic phase 2 glutathione-S-transferase enzymatic pathway that conjugates exogenous toxins and xenobiotics (e.g medications, pesticides, alcohol), and as part of glutathione peroxidase that neutralises hydrogen peroxide free radicals and lipid oxidative damage

In AD patients, the GSH content is reduced ( Lipid metabolism and alzheimers disease Recent studies have shown that lipid ROS in ferroptosis may cause AD