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Development of PD-1 and PD-L1 Inhibitors as a Form of Cancer Immunotherapy: A Comprehensive Review of Registration Trials and Future Considerations

10.1089/neu.2016.4413 48 Moreno-GonzalezI.SotoC

This points to a P2X 7 R-mediated mechanism, in which [Ca 2+ ]i levels may promote GABA release through reversal of the GAT transporter activity ( GSH induces [Ca 2+ ]i transients and GABA release through glial P2X 7 R Previous data have shown that activation of P2X 7 R in rat hippocampal slices leads to GABA release