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Methods A systematic search in the literature was performed in PubMed, Scopus, Embase, Cochrane Library, Web of Science, as well as Google Scholar pre-print database using all available MeSH terms for COVID-19, Coronavirus, SARS-CoV-2, senescent cell, cytokine storm, inflame-aging, ACE2 receptor, autophagy, and Vitamin D

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414 Pentoxifylline was also found to lower the risk of a dangerous blood clotting disorder in premature newborns, 415 and appeared to be helpful in treating a similar clotting emergency in adult patients with severe blood infections

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