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The gut virome of individuals with DM exhibits characteristic alterations, including an enrichment of Caudovirales phages, which enhance antibiotic resistance in pathogens (e.g., Klebsiella pneumoniae ) via horizontal gene transfer

This therapeutic network was i) validated by two independent treatment datasets of patients with depression and a prospective preclinical experiment on male rats, ii) associated with networks of depression-related genes, neurotransmitters, and cognitions, and iii) also the target network of deep brain stimulation and repetitive transcranial magnetic stimulation (rTMS)

Bergman RN, Kim SP, Hsu IR, Catalano KJ, Chiu JD, Kabir M, Richey JM, Ader M: Abdominal obesity: role in the pathophysiology of metabolic disease and cardiovascular risk