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A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish berberis species

ALA exits the mitochondria, and the next cytoplasmic steps involve pairwise condensation of two ALA molecules by ALA dehydratase (PBGS) to form porphobilinogen (PBG), followed by tetrapyrrole assembly: PBG deaminase (HMBS) polymerizes four PBG units to hydroxymethylbilane (HMB), and uroporphyrinogen III synthase (UROS) cyclizes HMB to uroporphyrinogen III (with asymmetric orientation of the D ring)