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10.1016/j.biopha.2023.115892 39 ValdsK.MoralesJ.RodrguezL.GntherG

It contains zinc-finger domains that bind to DNA, as well as a ligand-binding site that ensures specific activation by calcitriol ( Calcitriol also exerts rapid, non-genomic effects through the 1,25D-MARRS receptor (PDIA3), which is highly expressed in neurons, astrocytes, and endothelial cells ( Taken together, the widespread expression of VDRs and vitamin Dmetabolizing enzymes throughout the aging brain supports the plausibility of vitamin D as a neuromodulator in later life

Similarly, Lactiplantibacillus plantarum CGMCC 20032 shows inhibitory effects on Staphylococcus aureus , Aeromonas hydrophila , Aeromonas veronii , Cronobacter sakazakii , and Salmonella Typhimurium [51]

Most researchers notice gradual return toward baseline over weeks to months after stopping