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2.2.1 CD8+ T cells: modulation by bile acids in effector function, exhaustion, and ICI response Cytotoxic CD8 + T lymphocytes are central effectors in the TIME, and their function strongly influences anti-tumor immunity and immune checkpoint inhibitor (ICI) efficacy ( + T cell activity and ICI responsiveness ( Certain BAs can bidirectionally regulate CD8 + T cell effector functions directly

The relationship between glutathione and liver health has prompted interest in supplementation as a potential supportive measure, though it is important to note that glutathione supplements are not currently recommended by NICE or the NHS for the treatment of fatty liver disease

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