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This might happen if: Weight loss progress slows down Side effects are difficult to tolerate Blood sugar levels require better management Another medication may be better suited to the patients metabolism Instead of combining medications, providers typically transition patients carefully from one medication to another

Many physiopathological processes, both normal and abnormal, have been associated with DNA methylation (especially 5mC) (see Fig

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6.5 Emerging challenges and research priorities in intervention development While current intervention strategies have demonstrated measurable benefits in reducing EED exposure, several fundamental challenges limit their broader implementation and effectiveness