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In celiac disease, overproduction of zonulin causes these tight junctions to come apart and remain open, increasing intestinal permeability (Tripathi 2009

19212654DNAhomo sapiensCDS(1286)..(2464)1 caaggttctg aaggaaacaa ggtcaagagg acatcctgca tgtatggggc aaactgctat 60 aggaagaatc ctgttcattt tcaacatttt agccatcctg gtgatagtga ttatggaggt 120 gtacaaatcg tgggccaaga tgagactgat gaccggcctg aatgtcccta tggaccatcc 180 tgttatagga agaatcccca gcacaagata gaatatagac ataatacgct tccagtgaga 240 aatgttttag atgaagataa tgataatgtt gggcaaccca atgagtatga cctgaacgac 300 agctttctag atgatgagga agaagactat gagccaacag atgaagattc tgactgggaa 360 ccaggaaagg aagatgaaga gaaggaagat gtggaagagc ttttgaaaga agcaaaaagc 420 aaataatttc ccgcatcttc actcttcatc ttcccaccct cttctggaca actcctgaca 480 ttctgtgata ttcagcattc accataaaca ttgcatgatt cagttctcct tgatatcttg 540 gtgcttggac tcttcactgt tggcatcatt aggtcagcag gtgaacactc aggattgttt 600 ctcttctgtt agtagagcac caaaagacag ggtctggctc tgtcacctaa gccagagggc 660 aatggtacaa tcaccattga ctgcagtctc aaattcctgg gctcaagcaa tcctcccgcc 720 tcagcttccc aagcagctgg gactacaggc atgccccacc atgtccaggg aatggtgtct 780 ggacccagag aataactgga tcttcaagga aggaagagaa atcttcagaa gaacatggat 840 tttccccact ggtagttagt tgtctcttcc atatccagaa ataacttgaa cacgttagac 900 ggggccactg tgcatagtgt cctcccagga aaacgccaag attctccaag acactttcat 960 atcctaagcc ctgttctgtt tgttcttgtg tagtaaattg gcaaatttgg cagtacagaa 1020 gacatctcta acctgatgtc acaaagaatc atgtctggcc catacaaagt attctaacta 1080 accatgtaag ccactagaat gttaaactaa tgctctggca ctgaggttta gaatggagct 1140 cagataccat accccaaaga tgctggcaga gacattctga ctcattaagg gagagctggc 1200 tgatagcaga gaggggtgac atcagccttg cagacattgc cctggggaat tctgagcagt 1260 gttgctcaca gcaccacctg gccag atg gag acc acc atg ggg ttc atg gat 1312 Met Glu Thr Thr Met Gly Phe Met Asp 1 5 gac aat gcc acc aac act tcc acc agc ttc ctt tct gtg ctc aac cct 1360 Asp Asn Ala Thr Asn Thr Ser Thr Ser Phe Leu Ser Val Leu Asn Pro 10 15 20 25 cat gga gcc cat gcc act tcc ttc cca ttc aac ttc agc tac agc gac 1408 His Gly Ala His Ala Thr Ser Phe Pro Phe Asn Phe Ser Tyr Ser Asp 30 35 40 tat gat atg cct ttg gat gaa gat gag gat gtg acc aat tcc agg acg 1456 Tyr Asp Met Pro Leu Asp Glu Asp Glu Asp Val Thr Asn Ser Arg Thr 45 50 55 ttc ttt gct gcc aag att gtc att ggg atg gcc ctg gtg ggc atc atg 1504 Phe Phe Ala Ala Lys Ile Val Ile Gly Met Ala Leu Val Gly Ile Met 60 65 70 ctg gtc tgc ggc att gga aac ttc atc ttt atc gct gcc ctg gtc cgc 1552 Leu Val Cys Gly Ile Gly Asn Phe Ile Phe Ile Ala Ala Leu Val Arg 75 80 85 tac aag aaa ctg cgc aac ctc acc aac ctg ctc atc gcc aac ctg gcc 1600 Tyr Lys Lys Leu Arg Asn Leu Thr Asn Leu Leu Ile Ala Asn Leu Ala 90 95 100 105 atc tct gac ttc ctg gtg gcc att gtc tgc tgc ccc ttt gag atg gac 1648 Ile Ser Asp Phe Leu Val Ala Ile Val Cys Cys Pro Phe Glu Met Asp 110 115 120 tac tat gtg gtg cgc cag ctc tcc tgg gag cac ggc cac gtc ctg tgc 1696 Tyr Tyr Val Val Arg Gln Leu Ser Trp Glu His Gly His Val Leu Cys 125 130 135 acc tct gtc aac tac ctg cgc act gtc tct ctc tat gtc tcc acc aat 1744 Thr Ser Val Asn Tyr Leu Arg Thr Val Ser Leu Tyr Val Ser Thr Asn 140 145 150 gcc ctg ctg gcc atc gcc att gac agg tat ctg gct att gtc cat ccg 1792 Ala Leu Leu Ala Ile Ala Ile Asp Arg Tyr Leu Ala Ile Val His Pro 155 160 165 ctg aga cca cgg atg aag tgc caa aca gcc act ggc ctg att gcc ttg 1840 Leu Arg Pro Arg Met Lys Cys Gln Thr Ala Thr Gly Leu Ile Ala Leu 170 175 180 185 gtg tgg acg gtg tcc atc ctg atc gcc atc cct tcc gcc tac ttc acc 1888 Val Trp Thr Val Ser Ile Leu Ile Ala Ile Pro Ser Ala Tyr Phe Thr 190 195 200 acc gag acg gtc ctc gtc att gtc aag agc cag gaa aag atc ttc tgc 1936 Thr Glu Thr Val Leu Val Ile Val Lys Ser Gln Glu Lys Ile Phe Cys 205 210 215 ggc cag atc tgg cct gtg gac cag cag ctc tac tac aag tcc tac ttc 1984 Gly Gln Ile Trp Pro Val Asp Gln Gln Leu Tyr Tyr Lys Ser Tyr Phe 220 225 230 ctc ttt atc ttt ggc ata gaa ttc gtg ggc ccc gtg gtc acc atg acc 2032 Leu Phe Ile Phe Gly Ile Glu Phe Val Gly Pro Val Val Thr Met Thr 235 240 245 ctg tgc tat gcc agg atc tcc cgg gag ctc tgg ttc aag gcg gtc cct 2080 Leu Cys Tyr Ala Arg Ile Ser Arg Glu Leu Trp Phe Lys Ala Val Pro 250 255 260 265 gga ttc cag aca gag cag atc cgc aag agg ctg cgc tgc cgc agg aag 2128 Gly Phe Gln Thr Glu Gln Ile Arg Lys Arg Leu Arg Cys Arg Arg Lys 270 275 280 acg gtc ctg gtg ctc atg tgc atc ctc acc gcc tac gtg cta tgc tgg 2176 Thr Val Leu Val Leu Met Cys Ile Leu Thr Ala Tyr Val Leu Cys Trp 285 290 295 gcg ccc ttc tac ggc ttc acc atc gtg cgc gac ttc ttc ccc acc gtg 2224 Ala Pro Phe Tyr Gly Phe Thr Ile Val Arg Asp Phe Phe Pro Thr Val 300 305 310 ttt gta aag gag aag cac tac ctc act gcc ttc tac atc gtc gag tgc 2272 Phe Val Lys Glu Lys His Tyr Leu Thr Ala Phe Tyr Ile Val Glu Cys 315 320 325 atc gcc atg agc aac agc atg atc aac act ctg tgc ttc gtg acc gtc 2320 Ile Ala Met Ser Asn Ser Met Ile Asn Thr Leu Cys Phe Val Thr Val 330 335 340 345 aag aac gac acc gtc aag tac ttc aaa aag atc atg ttg ctc cac tgg 2368 Lys Asn Asp Thr Val Lys Tyr Phe Lys Lys Ile Met Leu Leu His Trp 350 355 360 aag gct tct tac aat ggc ggt aag tcc agt gca gac ctg gac ctc aag 2416 Lys Ala Ser Tyr Asn Gly Gly Lys Ser Ser Ala Asp Leu Asp Leu Lys 365 370 375 aca att ggg atg cct gcc acc gaa gag gtg gac tgc atc aga cta aaa 2464 Thr Ile Gly Met Pro Ala Thr Glu Glu Val Asp Cys Ile Arg Leu Lys 380 385 390 taaccccctg gactttgcaa agtttaaaca caaagcaggg tcctgtggac actgactagt 2524 gtgcttggat gcacatcaac ctggaacttt ttgtttgctg cagagggtaa agtaaatgga 2584 ccactctgtg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 2644 aaaaaaaaaa 26542393PRThomo sapiens2 Met Glu Thr Thr Met Gly Phe Met Asp Asp Asn Ala Thr Asn Thr Ser 1 5 10 15 Thr Ser Phe Leu Ser Val Leu Asn Pro His Gly Ala His Ala Thr Ser 20 25 30 Phe Pro Phe Asn Phe Ser Tyr Ser Asp Tyr Asp Met Pro Leu Asp Glu 35 40 45 Asp Glu Asp Val Thr Asn Ser Arg Thr Phe Phe Ala Ala Lys Ile Val 50 55 60 Ile Gly Met Ala Leu Val Gly Ile Met Leu Val Cys Gly Ile Gly Asn 65 70 75 80 Phe Ile Phe Ile Ala Ala Leu Val Arg Tyr Lys Lys Leu Arg Asn Leu 85 90 95 Thr Asn Leu Leu Ile Ala Asn Leu Ala Ile Ser Asp Phe Leu Val Ala 100 105 110 Ile Val Cys Cys Pro Phe Glu Met Asp Tyr Tyr Val Val Arg Gln Leu 115 120 125 Ser Trp Glu His Gly His Val Leu Cys Thr Ser Val Asn Tyr Leu Arg 130 135 140 Thr Val Ser Leu Tyr Val Ser Thr Asn Ala Leu Leu Ala Ile Ala Ile 145 150 155 160 Asp Arg Tyr Leu Ala Ile Val His Pro Leu Arg Pro Arg Met Lys Cys 165 170 175 Gln Thr Ala Thr Gly Leu Ile Ala Leu Val Trp Thr Val Ser Ile Leu 180 185 190 Ile Ala Ile Pro Ser Ala Tyr Phe Thr Thr Glu Thr Val Leu Val Ile 195 200 205 Val Lys Ser Gln Glu Lys Ile Phe Cys Gly Gln Ile Trp Pro Val Asp 210 215 220 Gln Gln Leu Tyr Tyr Lys Ser Tyr Phe Leu Phe Ile Phe Gly Ile Glu 225 230 235 240 Phe Val Gly Pro Val Val Thr Met Thr Leu Cys Tyr Ala Arg Ile Ser 245 250 255 Arg Glu Leu Trp Phe Lys Ala Val Pro Gly Phe Gln Thr Glu Gln Ile 260 265 270 Arg Lys Arg Leu Arg Cys Arg Arg Lys Thr Val Leu Val Leu Met Cys 275 280 285 Ile Leu Thr Ala Tyr Val Leu Cys Trp Ala Pro Phe Tyr Gly Phe Thr 290 295 300 Ile Val Arg Asp Phe Phe Pro Thr Val Phe Val Lys Glu Lys His Tyr 305 310 315 320 Leu Thr Ala Phe Tyr Ile Val Glu Cys Ile Ala Met Ser Asn Ser Met 325 330 335 Ile Asn Thr Leu Cys Phe Val Thr Val Lys Asn Asp Thr Val Lys Tyr 340 345 350 Phe Lys Lys Ile Met Leu Leu His Trp Lys Ala Ser Tyr Asn Gly Gly 355 360 365 Lys Ser Ser Ala Asp Leu Asp Leu Lys Thr Ile Gly Met Pro Ala Thr 370 375 380 Glu Glu Val Asp Cys Ile Arg Leu Lys 385 3903355PRThomo sapiens3 Tyr Gly Asp Tyr Asp Leu Pro Met Asp Glu Asp Glu Asp Met Thr Lys 1 5 10 15 Thr Arg Thr Phe Phe Ala Ala Lys Ile Val Ile Gly Ile Ala Leu Ala 20 25 30 Gly Ile Met Leu Val Cys Gly Ile Gly Asn Phe Val Phe Ile Ala Ala 35 40 45 Leu Thr Arg Tyr Lys Lys Leu Arg Asn Leu Thr Asn Leu Leu Ile Ala 50 55 60 Asn Leu Ala Ile Ser Asp Phe Leu Val Ala Ile Ile Cys Cys Pro Phe 65 70 75 80 Glu Met Asp Tyr Tyr Val Val Arg Gln Leu Ser Trp Glu His Gly His 85 90 95 Val Leu Cys Ala Ser Val Asn Tyr Leu Arg Thr Val Ser Leu Tyr Val 100 105 110 Ser Thr Asn Ala Leu Leu Ala Ile Ala Ile Asp Arg Tyr Leu Ala Ile 115 120 125 Val His Pro Leu Lys Pro Arg Met Asn Tyr Gln Thr Ala Ser Phe Leu 130 135 140 Ile Ala Leu Val Trp Met Val Ser Ile Leu Ile Ala Ile Pro Ser Ala 145 150 155 160 Tyr Phe Ala Thr Glu Thr Val Leu Phe Ile Val Lys Ser Gln Glu Lys 165 170 175 Ile Phe Cys Gly Gln Ile Trp Pro Val Asp Gln Gln Leu Tyr Tyr Lys 180 185 190 Ser Tyr Phe Leu Phe Ile Phe Gly Val Glu Phe Val Gly Pro Val Val 195 200 205 Thr Met Thr Leu Cys Tyr Ala Arg Ile Ser Arg Glu Leu Trp Phe Lys 210 215 220 Ala Val Pro Gly Phe Gln Thr Glu Gln Ile Arg Lys Arg Leu Arg Cys 225 230 235 240 Arg Arg Lys Thr Val Leu Val Leu Met Cys Ile Leu Thr Ala Tyr Val 245 250 255 Leu Cys Trp Ala Pro Phe Tyr Gly Phe Thr Ile Val Arg Asp Phe Phe 260 265 270 Pro Thr Val Phe Val Lys Glu Lys His Tyr Leu Thr Ala Phe Tyr Val 275 280 285 Val Glu Cys Ile Ala Met Ser Asn Ser Met Ile Asn Thr Val Cys Phe 290 295 300 Val Thr Val Lys Asn Asn Thr Met Lys Tyr Phe Lys Lys Met Met Leu 305 310 315 320 Leu His Trp Arg Pro Ser Gln Arg Gly Ser Lys Ser Ser Ala Asp Leu 325 330 335 Asp Leu Arg Thr Asn Gly Val Pro Thr Thr Glu Glu Val Asp Cys Ile 340 345 350 Arg Leu Lys 3554393PRTMus musculus4 Met Glu Thr Thr Val Gly Ala Leu Gly Glu Asn Thr Thr Asp Thr Phe 1 5 10 15 Thr Asp Phe Phe Ser Ala Leu Asp Gly His Glu Ala Gln Thr Gly Ser 20 25 30 Leu Pro Phe Thr Phe Ser Tyr Gly Asp Tyr Asp Met Pro Leu Asp Glu 35 40 45 Glu Glu Asp Val Thr Asn Ser Arg Thr Phe Phe Ala Ala Lys Ile Val 50 55 60 Ile Gly Met Ala Leu Val Gly Ile Met Leu Val Cys Gly Ile Gly Asn 65 70 75 80 Phe Ile Phe Ile Thr Ala Leu Ala Arg Tyr Lys Lys Leu Arg Asn Leu 85 90 95 Thr Asn Leu Leu Ile Ala Asn Leu Ala Ile Ser Asp Phe Leu Val Ala 100 105 110 Ile Val Cys Cys Pro Phe Glu Met Asp Tyr Tyr Val Val Arg Gln Leu 115 120 125 Ser Trp Glu His Gly His Val Leu Cys Ala Ser Val Asn Tyr Leu Arg 130 135 140 Thr Val Ser Leu Tyr Val Ser Thr Asn Ala Leu Leu Ala Ile Ala Ile 145 150 155 160 Asp Arg Tyr Leu Ala Ile Val His Pro Leu Arg Pro Arg Met Lys Cys 165 170 175 Gln Thr Ala Ala Gly Leu Ile Phe Leu Val Trp Ser Val Ser Ile Leu 180 185 190 Ile Ala Ile Pro Ala Ala Tyr Phe Thr Thr Glu Thr Val Leu Val Ile 195 200 205 Val Glu Arg Gln Glu Lys Ile Phe Cys Gly Gln Ile Trp Pro Val Asp 210 215 220 Gln Gln Phe Tyr Tyr Arg Ser Tyr Phe Leu Leu Val Phe Gly Leu Glu 225 230 235 240 Phe Val Gly Pro Val Val Ala Met Thr Leu Cys Tyr Ala Arg Val Ser 245 250 255 Arg Glu Leu Trp Phe Lys Ala Val Pro Gly Phe Gln Thr Glu Gln Ile 260 265 270 Arg Arg Thr Val Arg Cys Arg Arg Arg Thr Val Leu Gly Leu Val Cys 275 280 285 Val Leu Ser Ala Tyr Val Leu Cys Trp Ala Pro Phe Tyr Gly Phe Thr 290 295 300 Ile Val Arg Asp Phe Phe Pro Ser Val Phe Val Lys Glu Lys His Tyr 305 310 315 320 Leu Thr Ala Phe Tyr Val Val Glu Cys Ile Ala Met Ser Asn Ser Met 325 330 335 Ile Asn Thr Leu Cys Phe Val Thr Val Arg Asn Asn Thr Ser Lys Tyr 340 345 350 Leu Lys Arg Ile Leu Arg Leu Gln Trp Arg Ala Ser Pro Ser Gly Ser 355 360 365 Lys Ala Ser Ala Asp Leu Asp Leu Arg Thr Thr Gly Ile Pro Ala Thr 370 375 380 Glu Glu Val Asp Cys Ile Arg Leu Lys 385 3905381PRTRattus norvegicus5 Met Gly Pro Leu Gly Ala Glu Ala Asp Glu Asn Gln Thr Val Glu Val 1 5 10 15 Lys Val Glu Leu Tyr Gly Ser Gly Pro Thr Thr Pro Arg Gly Glu Leu 20 25 30 Pro Pro Asp Pro Glu Pro Glu Leu Ile Asp Ser Thr Lys Leu Val Glu 35 40 45 Val Gln Val Val Leu Ile Leu Ala Tyr Cys Ser Ile Ile Leu Leu Gly 50 55 60 Val Val Gly Asn Ser Leu Val Ile His Val Val Ile Lys Phe Lys Ser 65 70 75 80 Met Arg Thr Val Thr Asn Phe Phe Ile Ala Asn Leu Ala Val Ala Asp 85 90 95 Leu Leu Val Asn Thr Leu Cys Leu Pro Phe Thr Leu Thr Tyr Thr Leu 100 105 110 Met Gly Glu Trp Lys Met Gly Pro Val Leu Cys His Leu Val Pro Tyr 115 120 125 Ala Gln Gly Leu Ala Val Gln Val Ser Thr Ile Thr Leu Thr Val Ile 130 135 140 Ala Leu Asp Arg His Arg Cys Ile Val Tyr His Leu Glu Ser Lys Ile 145 150 155 160 Ser Lys Gln Ile Ser Phe Leu Ile Ile Gly Leu Ala Trp Gly Val Ser 165 170 175 Ala Leu Leu Ala Ser Pro Leu Ala Ile Phe Arg Glu Tyr Ser Leu Ile 180 185 190 Glu Ile Ile Pro Asp Phe Glu Ile Val Ala Cys Thr Glu Lys Trp Pro 195 200 205 Gly Glu Glu Lys Ser Val Tyr Gly Thr Val Tyr Ser Leu Ser Thr Leu 210 215 220 Leu Ile Leu Tyr Val Leu Pro Leu Gly Ile Ile Ser Phe Ser Tyr Thr 225 230 235 240 Arg Ile Trp Ser Lys Leu Lys Asn His Val Ser Pro Gly Ala Ala Ser 245 250 255 Asp His Tyr His Gln Arg Arg His Lys Thr Thr Lys Met Leu Val Cys 260 265 270 Val Val Val Val Phe Ala Val Ser Trp Leu Pro Leu His Ala Phe Gln 275 280 285 Leu Ala Val Asp Ile Asp Ser His Val Leu Asp Leu Lys Glu Tyr Lys 290 295 300 Leu Ile Phe Thr Val Phe His Ile Ile Ala Met Cys Ser Thr Phe Ala 305 310 315 320 Asn Pro Leu Leu Tyr Gly Trp Met Asn Ser Asn Tyr Arg Lys Ala Phe 325 330 335 Leu Ser Ala Phe Arg Cys Glu Gln Arg Leu Asp Ala Ile His Ser Glu 340 345 350 Val Ser Met Thr Phe Lys Ala Lys Lys Asn Leu Glu Val Lys Lys Asn 355 360 365 Asn Gly Leu Thr Asp Ser Phe Ser Glu Ala Thr Asn Val 370 375 3806385PRTGallus gallus6 Met Gly Pro Leu Glu Ala Ile Gly Glu Glu Asn Gln Thr Asp Glu Met 1 5 10 15 Lys Met Glu Leu Phe Thr Lys Leu Tyr Leu Pro Arg Tyr Thr Thr Pro 20 25 30 Val Ser Glu Leu Ala Leu Asp Pro Lys Pro Glu Leu Lys Asp Ser Thr 35 40 45 Thr Leu Val Glu Val Gln Ile Ile Leu Ile Phe Ala Tyr Cys Ser Ile 50 55 60 Ile Leu Leu Gly Val Ile Gly Asn Ser Leu Val Ile His Val Ile Ile 65 70 75 80 Lys Phe Lys Ser Met Arg Thr Val Thr Asn Phe Phe Ile Ala Asn Leu 85 90 95 Ala Val Ala Asp Leu Leu Val Asn Thr Leu Cys Leu Pro Phe Thr Leu 100 105 110 Val Tyr Thr Leu Leu Gly Glu Trp Lys Leu Gly Pro Val Leu Cys His 115 120 125 Leu Val Pro Tyr Ala Gln Ala Leu Ala Val His Val Ser Thr Val Thr 130 135 140 Leu Thr Val Ile Ala Leu Asp Arg His Arg Cys Ile Val Tyr His Leu 145 150 155 160 Glu Ser Lys Ile Ser Lys Arg Ile Ser Phe Leu Ile Ile Gly Val Ala 165 170 175 Trp Ala Val Ser Ala Leu Leu Ala Ser Pro Leu Ala Ile Phe Arg Glu 180 185 190 Tyr Ser Leu Ile Glu Ile Ile Pro Asp Phe Lys Ile Val Val Cys Ser 195 200 205 Glu Lys Trp Pro Gly Glu Gly Gln Leu Asn Tyr Gly Thr Ile Tyr Ser 210 215 220 Val Ser Met Leu Leu Ile Gln Tyr Val Leu Pro Leu Ala Ile Ile Ser 225 230 235 240 Tyr Ala Tyr Thr Arg Ile Trp Thr Lys Leu Lys Asn His Val Ser Pro 245 250 255 Gly Ala Gly Asn Asp His Tyr His His Arg Arg Gln Lys Thr Thr Lys 260 265 270 Met Leu Val Cys Val Val Val Val Phe Ala Val Ser Trp Leu Pro Phe 275 280 285 His Ala Phe Gln Leu Val Ser Asp Ile Asp Ser Gln Val Leu Asp Leu 290 295 300 Lys Glu Tyr Lys Leu Ile Tyr Thr Val Phe His Val Ile Ala Met Cys 305 310 315 320 Ser Thr Phe Ala Asn Pro Leu Leu Tyr Gly Trp Met Asn Asn Asn Tyr 325 330 335 Arg Thr Ala Phe Leu Thr Ala Phe Gln Cys Glu Gln Arg Leu Asp Ser 340 345 350 Ile His Pro Glu Val Ser Ala Ala Phe Lys Ala Arg Lys Lys Leu Glu 355 360 365 Ala Lys Lys Ser Gln Phe Pro Gly Asp Ser Phe Thr Gln Pro Thr Asn 370 375 380 Val 385780DNAhomo sapiens7 atgaagatga ggatgtgacc aattccagga cgttctttgc tgccaagatt gtcattggga 60 tggccctggt gggcatcatg 80820DNAhomo sapiens8 ggccatttca gatctcctgt 20920DNAhomo sapiens9 ctgaagggaa gcgtgcttat 201020DNAhomo sapiens10 gggaattctg agcagtgttg 201125DNAhomo sapiens11 ttcacagagt ggtccattta cttta 251225PRThomo sapiens12 Ile Val Ile Gly Met Ala Leu Val Gly Ile Met Leu Val Cys Gly Ile 1 5 10 15 Gly Asn Phe Ile Phe Ile Ala Ala Leu 20 251322PRThomo sapiens13 Leu Leu Ile Ala Asn Leu Ala Ile Ser Asp Phe Leu Val Ala Ile Val 1 5 10 15 Cys Cys Pro Phe Glu Met 201426PRThomo sapiens14 Thr Val Ser Leu Tyr Val Ser Thr Asn Ala Leu Leu Ala Ile Ala Ile 1 5 10 15 Asp Arg Tyr Leu Ala Ile Val His Pro Leu 20 251522PRThomo sapiens15 Ala Thr Gly Leu Ile Ala Leu Val Trp Thr Val Ser Ile Leu Ile Ala 1 5 10 15 Ile Pro Ser Ala Tyr Phe 201622PRThomo sapiens16 Tyr Phe Leu Phe Ile Phe Gly Ile Glu Phe Val Gly Pro Val Val Thr 1 5 10 15 Met Thr Leu Cys Tyr Ala 201720PRThomo sapiens17 Thr Val Leu Val Leu Met Cys Ile Leu Thr Ala Tyr Val Leu Cys Trp 1 5 10 15 Ala Pro Phe Tyr 201824PRThomo sapiens18 Thr Ala Phe Tyr Ile Val Glu Cys Ile Ala Met Ser Asn Ser Met Ile 1 5 10 15 Asn Thr Leu Cys Phe Val Thr Val 201914PRThomo sapiens19 Gly Phe Met Asp Asp Asn Ala Thr Asn Thr Ser Thr Ser Phe 1 5 102014PRThomo sapiens20 Asp Asp Asn Ala Thr Asn Thr Ser Thr Ser Phe Leu Ser Val 1 5 102114PRThomo sapiens21 Thr Ser Phe Pro Phe Asn Phe Ser Tyr Ser Asp Tyr Asp Met 1 5 102214PRThomo sapiens22 Tyr Lys Lys Leu Arg Asn Leu Thr Asn Leu Leu Ile Ala Asn 1 5 102314PRThomo sapiens23 Phe Val Thr Val Lys Asn Asp Thr Val Lys Tyr Phe Lys Lys 1 5 102413PRThomo sapiens24 Thr Leu Cys Phe Val Thr Val Lys Asn Asp Thr Val Lys 1 5 102513PRThomo sapiens25 Thr Val Lys Asn Asp Thr Val Lys Tyr Phe Lys Lys Ile 1 5 102618PRThomo sapiens26 Leu Leu His Trp Lys Ala Ser Tyr Asn Gly Gly Lys Ser Ser Ala Asp 1 5 10 15 Leu Asp2727PRThomo sapiens27 Thr Val Ser Leu Tyr Val Ser Thr Asn Ala Leu Leu Ala Ile Ala Ile 1 5 10 15 Asp Arg Tyr Leu Ala Ile Val His Pro Leu Arg 20 25288PRTbacteriophage T728 Asp Tyr Lys Asp Asp Asp Asp Lys 1 529733DNAhomo sapiens29 gggatccgga gcccaaatct tctgacaaaa ctcacacatg cccaccgtgc ccagcacctg 60 aattcgaggg tgcaccgtca gtcttcctct tccccccaaa acccaaggac accctcatga 120 tctcccggac tcctgaggtc acatgcgtgg tggtggacgt aagccacgaa gaccctgagg 180 tcaagttcaa ctggtacgtg gacggcgtgg aggtgcataa tgccaagaca aagccgcggg 240 aggagcagta caacagcacg taccgtgtgg tcagcgtcct caccgtcctg caccaggact 300 ggctgaatgg caaggagtac aagtgcaagg tctccaacaa agccctccca acccccatcg 360 agaaaaccat ctccaaagcc aaagggcagc cccgagaacc acaggtgtac accctgcccc 420 catcccggga tgagctgacc aagaaccagg tcagcctgac ctgcctggtc aaaggcttct 480 atccaagcga catcgccgtg gagtgggaga gcaatgggca gccggagaac aactacaaga 540 ccacgcctcc cgtgctggac tccgacggct ccttcttcct ctacagcaag ctcaccgtgg 600 acaagagcag gtggcagcag gggaacgtct tctcatgctc cgtgatgcat gaggctctgc 660 acaaccacta cacgcagaag agcctctccc tgtctccggg taaatgagtg cgacggccgc 720 gactctagag gat 7333023DNAHomo sapiens30 caggctgtgc tcactcagcc gtc 233123DNAHomo sapiens31 aattttatgc tgactcagcc cca 233238DNAHomo sapiens32 gcagcagcgg ccgcacttcc ttcccattca acttcagc 383336DNAHomo sapiens33 gcagcagtcg acttttagtc tgatgcagtc cacctc 363439DNAHomo sapiens34 gcagcagcgg ccgcatggag accaccatgg ggttcatgg 393537DNAHomo sapiens35 gcagcagtcg accttgacgg tcacgaagca cagagtg 373620DNAHomo sapiens36 cgtcctgtgc acctctgtca 203716DNAHomo sapiens37 tggccagcag ggcatt 163831DNAHomo sapiens38 tacctgcgca ctgtctctct ctatgtctcc a 313940DNAHomo sapiens39 cccaagcttg caccatggag accaccatgg ggttcatgga 404069DNAHomo sapiens40 gtccgggatc cctacttgtc gtcgtcgtcc ttgtagtcca tttttagtct gatgcagtcc 60 acctcttcg 694199DNAArtificial SequenceSynthesized Random Oligonucleotide.41 cgaagcgtaa gggcccagcc ggccnnbnnb nnbnnbnnbn nbnnbnnbnn bnnbnnbnnb 60 nnbnnbnnbn nbnnbnnbnn bnnbccgggt ccgggcggc 994295DNAArtificial SequenceSynthesized Random Oligonucleotide.42 aaaaggaaaa aagcggccgc vnnvnnvnnv nnvnnvnnvn nvnnvnnvnn vnnvnnvnnv 60 nnvnnvnnvn nvnnvnnvnn gccgcccgga cccgg 954325DNAArtificial SequenceSynthesized Oligonucleotide.43 auccugagug uucaccugcu gaccu 254425DNAArtificial SequenceSynthesized Oligonucleotide.44 uuggcccacg auuuguacac cucca 254525DNAArtificial SequenceSynthesized Oligonucleotide.45 acaugagcac caggaccguc uuccu 254625DNAArtificial SequenceSynthesized Oligonucleotide.46 cacagaaugu caggaguugu ccaga 254725DNAArtificial SequenceSynthesized Oligonucleotide.47 ggacauucag gccggucauc agucu 254816DNAHomo sapiens48 cccggtggac cacgaa 164919DNAHomo sapiens49 ggctcgcctc ttccatgtc 195025DNAHomo sapiens50 aacccgggac ttggagaagc actgc 255124DNAHomo sapiens51 gaggatgagg agagctatga caca 245222DNAHomo sapiens52 ccctttgcac tcataacgtc ag 225329DNAHomo sapiens53 aaacacacag tcatcatagg gcagctcgt 295423DNAHomo sapiens54 caggtgcagc tggtgcagtc tgg 235523DNAHomo sapiens55 caggtcaact taagggagtc tgg 235623DNAHomo sapiens56 gaggtgcagc tggtggagtc tgg 235723DNAHomo sapiens57 caggtgcagc tgcaggagtc ggg 235823DNAHomo sapiens58 gaggtgcagc tgttgcagtc tgc 235923DNAHomo sapiens59 caggtacagc tgcagcagtc agg 236024DNAHomo sapiens60 tgaggagacg gtgaccaggg tgcc 246124DNAHomo sapiens61 tgaagagacg gtgaccattg tccc 246224DNAHomo sapiens62 tgaggagacg gtgaccaggg ttcc 246324DNAHomo sapiens63 tgaggagacg gtgaccgtgg tccc 246423DNAHomo sapiens64 gacatccaga tgacccagtc tcc 236523DNAHomo sapiens65 gatgttgtga tgactcagtc tcc 236623DNAHomo sapiens66 gatattgtga tgactcagtc tcc 236723DNAHomo sapiens67 gaaattgtgt tgacgcagtc tcc 236823DNAHomo sapiens68 gacatcgtga tgacccagtc tcc 236923DNAHomo sapiens69 gaaacgacac tcacgcagtc tcc 237023DNAHomo sapiens70 gaaattgtgc tgactcagtc tcc 237123DNAHomo sapiens71 cagtctgtgt tgacgcagcc gcc 237223DNAHomo sapiens72 cagtctgccc tgactcagcc tgc 237323DNAHomo sapiens73 tcctatgtgc tgactcagcc acc 237423DNAHomo sapiens74 tcttctgagc tgactcagga ccc 237523DNAHomo sapiens75 cacgttatac tgactcaacc gcc 237623DNAHomo sapiens76 caggctgtgc tcactcagcc gtc 237723DNAHomo sapiens77 aattttatgc tgactcagcc cca 237824DNAHomo sapiens78 acgtttgatt tccaccttgg tccc 247924DNAHomo sapiens79 acgtttgatc tccagcttgg tccc 248024DNAHomo sapiens80 acgtttgata tccactttgg tccc 248124DNAHomo sapiens81 acgtttgatc tccaccttgg tccc 248224DNAHomo sapiens82 acgtttaatc tccagtcgtg tccc 248323DNAHomo sapiens83 cagtctgtgt tgacgcagcc gcc 238423DNAHomo sapiens84 cagtctgccc tgactcagcc tgc 238523DNAHomo sapiens85 tcctatgtgc tgactcagcc acc 238623DNAHomo sapiens86 tcttctgagc tgactcagga ccc 238723DNAHomo sapiens87 cacgttatac tgactcaacc gcc 238815PRTArtificial SequenceSynthesized Random Peptide.88 Val Asp Thr Phe Phe Glu Asp Ile Pro Trp Gly Phe Val Leu Phe 1 5 10 158915PRTArtificial SequenceSynthesized Random Peptide.89 Leu Phe Val Asp Lys Trp Asp Leu Ser Asn Phe Trp Gly Gly Gly 1 5 10 159015PRTArtificial SequenceSynthesized Random Peptide.90 Leu Phe Leu Glu Ala Trp Asp Leu Ser Asp Thr Pro His Leu Tyr 1 5 10 159115PRTArtificial SequenceSynthesized Random Peptide.91 Val Trp Gly Asn Ser Leu Ile Val Gly Arg Trp Asp Val Val Gly 1 5 10 159215PRTArtificial SequenceSynthesized Random Peptide.92 Ile Gly Gly Val Gly Asp Gly Leu Tyr Val Val Ser Trp Asp Leu 1 5 10 15 Claims (40) 1

No, unlike IGF-1 DES which benefits from site-specific injection, IGF-1 LR3's long half-life means it circulates systemically regardless of injection site