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6.3 Neurotransmitter systems Abnormalities in neurotransmitter systems, particularly imbalances in serotonergic (5-HT) and noradrenergic (NE) pathways, have been linked to chronic stress and may contribute to cognitive impairment in ME/CFS

Based on these models, they predicted that mitochondrial residency may be required to the formation of double-membrane vesicles which is a critical in corona virus being able to replicate un-abated by evading cellular defenses

Moreover, the gut microbiota and its associated metabolites promote the differentiation and function of anti-inflammatory macrophages, Treg cells, CD4 + CD8 + regulatory cells, IL-10 + and/or IL-35 + B regulatory cells, as well as IL-22-producing innate lymphoid cells 3 (ILC3), which are involved in maintaining the gut mucosal homeostasis (Su et al., 2022) and protecting the kidneys (Su et al., 2022)

Simonds, P.J