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In rare cases, a severe vitamin C deficiency can cause you to develop scurvy, marked by: Fatigue Joint and muscle pain Swollen and spongy gums Red spots on the skin Children with a vitamin D deficiency can develop rickets, which manifests as poor growth, deformities, and bone pain

Marnett LJ (2000) Oxyradicals and DNA damage

Additionally, inflammation in the gut may disrupt communication between intestinal cells and the endocrine system, affecting hormones that regulate appetite and energy expenditure

Women taking hormone replacement therapy often experience breakthrough bleeding, especially during the first few months of treatment