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Stagni et al., 2017) 5-Ethynyl-20-deoxyuridine (EdU

Common side effects reported with retatrutide include: Nausea, vomiting, and diarrhoea (most frequent, particularly during dose escalation) Decreased appetite Constipation Injection site reactions Mild increases in heart rate Cagrilintide has demonstrated a generally well-tolerated profile, with gastrointestinal symptoms also being the most commonly reported adverse effects

The replacement of Alanine 2 and 13 with Aib did not significantly change the binding affinity, but did result in a decline in potency as a substrate for DPP4