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Acquired PGA elevation can also occur during chronic acetaminophen use [67, 68] as acetaminophen metabolism consumes glutathione through conjugation reactions, thereby depleting GSH stores and increasing metabolic flux toward PGA formation [69]

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Acknowledgements This work was supported by the National Natural Science Foundation of China (21102182), the Natural Science Foundation of Jiangsu Province (BK2012760, China), Fundamental Research Funds for the Central Universities (2632018ZD09, China), and Excellent Science and Technology Innovation Team of Jiangsu Province Universities in 2015 (China)

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