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CCL2 (Fig

When the expression of Nrf2/ARE is at zero circadian time point, expression of glutamate-cysteine ligase modifier (GCLM), NAD(P)H dehydrogenase [quinone] 1 (NQO1), and heme oxygenase 1 (HMOX1) proteins are weakened, resulting in severe oxidative injury (Tonelli et al., 2018

In our own study we were able to show that LIF mRNA expression was up-regulated very early mainly during the first 3 weeks of cuprizone administration in both CC and cortex thereafter decreasing to normal levels in the recovery phase after toxin withdrawal (Gudi et al., 2011)

This is why the treatment approach I'll share addresses the entire chainnot just your heel