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A phase 1/2, dose-finding study to evaluate safety, tolerability, and immunogenicity of the ChulaCov19 vaccine in healthy adults (2020)

npj Metab Health Dis 2 , 31 (2024)

Unlike mitragynine, 7-hydroxymitragynine had little to no binding affinity to both alpha-1 and alpha-2 adrenoreceptors indicating that oxidation at the C-7 abolishes the interaction with these receptors