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FIGURE 3 TPPU and DHA + TPPU Decrease Inflammation in the Hippocampus of Diabetic Rats An increase in the neuroinflammation was evident in the hippocampus of diabetic rats due to the rise in the level of pro-inflammatory marker IL-1 (Figure 4A) (412 29 pg/ml) and IL-6 (Figure 4B) (180 6 pg/ml) and decrease in the level of anti-inflammatory marker IL-10 (Figure 4C) (220 7 pg/ml) in comparison to the healthy normal rats (IL-1, 311 14 pg/ml

Inhaled salmeterol: maximum 200 micrograms over 24 hours in divided doses not to exceed 100 micrograms over 8 hours starting from any dose Inhaled vilanterol: maximum 25 micrograms over 24 hours NOTE The presence in urine of salbutamol in excess of 1000 ng/mL or formoterol in excess of 40 ng/mL is not consistent with therapeutic use of the substance and will be considered as an Adverse Analytical Finding (AAF) unless the Athlete proves, through a controlled pharmacokinetic study, that the abnormal result was the consequence of a therapeutic dose (by inhalation) up to the maximum dose indicated above

Overcoming the shortcomings of peptide-based therapeutics