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this is due to the alkaline pKa of GGT substrates, which is above pH 9.0

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By maintaining hidden state connections across time steps, RNNs can retain information from previous inputs, making them highly effective for sequential data such as text, speech, and physiological signals [56, 57]

1, 12 As the name implies, TJ acts as a physical barrier whose function is to prevent free passage of ions and small solutes through the space between two interacting cells