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If you feel any of these to any degree it is time to take a break before you step beyond the event horizon and get KOd

"Most heavy users do not suffer from medical conditions as long as they don't smoke tobacco." Springer agreed that the new study doesn't directly prove harm in humans, but noted it has been established that rat circulatory systems have enough similarities with those of humans to make them useful in the laboratory

After 2 to 3 months, blood circulation improves and lung function increases by up to 30%