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Transdermal estradiol carries a lower risk of blood clots compared to oral formulations because it bypasses first-pass hepatic metabolism

Off-label use of tesamorelin in adults with visceral obesity and metabolic syndrome exists in clinical practice, and the mechanistic rationale is sound

Upon receptor binding, it initiates Gq-coupled intracellular signaling, thus activating phospholipase C, generating inositol trisphosphate, and mobilizing intracellular calcium

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