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3.2 Reaction mechanisms of antioxidant activity Using quantum chemical calculations, we showed that in an aqueous solution, the reaction between the radical and the -C-H bond at position 2 (Figure 1) was the only one resulting in negative reaction free energy, indicating a thermodynamically favorable reaction (Table 5), while in n- octanol no reaction between local anesthetic and peroxyl radical was thermodynamically favorable at any position (Table 5)