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These results suggest a state of increased excitability that develops in spinal pain-signaling neurons as a consequence of decreased glutamate clearance

Sagnella et al., 2018

10.1055/s-2002-19594 89 EgbelakinA.FergusonM

Some studies have found that people with FM have lower levels of 5-HT in their cerebrospinal fluid than healthy controls, which may contribute to the development of pain and other symptoms 19