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It reduced AGEs and receptor for advanced glycation end products (RAGE) expression, enhanced antioxidant enzyme activities (SOD, CAT, GSH-Px, T-AOC), and downregulated reduced the accumulation of AGEs and the expression of RAGE, increased activities of antioxidant enzymes (SOD, CAT, GSH-Px, T-AOC), and decreased levels of pro-inflammatory cytokines (TNF-, IL-1, IL-6) in a dose-dependent manner

The treatment of lactone 71 with thiourea in a strong mineral acid via alkaline hydrolysis of the isothiuronium salt easily yielded DHLA, which afforded the desired ALA after oxidation

Comput Struct Biotechnol J

Mann et al., 2016[84])