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Additionally, in order to understand the complex relationship between cancer cells and the TME, more research needs to focus on the cancer cells themselves, including looking at patient-derived multi-cell populations which, due to the heterogeneity of cancers, would be necessary to obtain more clinically relevant data

While the crosslinking mechanism using DNA-AuNPs involves laborious salt-assisted DNA immobilization, an alternative non-crosslinking approach uses unmodified AuNPs for simply distinguishing between ssDNA and double-stranded DNA (dsDNA)

Enhanced antitumor efficacy of MCNs/Ln/GD/FR NPs against subcutaneous tumor in vivo To assess the synergistic therapeutic effect of MCNs/Ln/GD/FR NPs on tumors in vivo, two types of melanoma models were established, including subcutaneous tumors and in situ ocular tumors, through localized injection of OCM-1 cells

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