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Gelam honey markedly inhibited these pathways in HIT-T15 pancreatic islet cells at concentrations as low as 20 g/mL ( In vivo , oral administration of Malasyian gelam honey (12 g/kg) reduced leukocyte infiltration and edema in carrageenan-induced rats, thus attenuating acute inflammatory responses ( Tualang honey, collected by Apis dorsata bees from Malaysian rainforests, is especially abundant in phenolic acids and flavonoids

In the transition metal chelation mechanism, polyphenol anions chelate heavy metals through the deprotonation of hydroxyl groups, forming metal complexes and releasing a proton (ArOH ArO + H+) (160)